Dimethyl Sulfoxide
Apexbio Technology LLC CVT-313 199986-75-9 10mM (in 1mL DMSO)
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Apexbio Technology LLC Oseltamivir 196618-13-0 10mM (in 1mL DMSO)
Oseltamivir is a neuraminidase inhibitor targeting influenza virus replication It functions as a prodrug metabolized into oseltamivir carboxylate by host esterases This active metabolite binds to viral neuraminidase thereby blocking cleavage of terminal -Neu5Ac residues and subsequent viral progeny release from infected host cells Oseltamivir has been widely employed in investigative studies addressing antiviral efficacy resistance mechanisms and clinical outcomes in influenza infection research The compound is frequently used in vitro to characterize neuraminidase activity inhibition typically reporting IC50 values in the low nanomolar range (approximately 0 1-5 nM) depending on the influenza viral strain and assay conditions influencing viral replication and transmission
Sigma Aldrich Fine Chemicals Biosciences Promethazine sulfoxide Bri
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Apexbio Technology LLC ANA 12 219766-25-3 10mM (in 1mL DMSO)
ANA 12 (CAS 219766-25-3) is a potent and selective antagonist of tropomyosin receptor kinase B (TrkB) the receptor for neurotrophins BDNF and NT-4/5 It binds non-competitively to extracellular sites on TrkB exhibiting IC50 values of 45 6 nM (high-affinity site) and 41 1 M (low-affinity site) ANA 12 inhibits BDNF-induced TrkB activation effectively blocking downstream signaling pathways including PLC- PI3K and MAPK In mouse models ANA 12 administration reduces endogenous brain TrkB activity and demonstrates antidepressant and anxiolytic properties supporting its use for researching psychiatric disorders and neuronal signaling
Apexbio Technology LLC Disulfiram 97-77-8 10mM (in 1mL DMSO)
Disulfiram (CAS 97-77-8) is a small molecule compound recognized as a copper ionophore facilitating intracellular transport of Cu ions It inhibits inflammasome-dependent pyroptotic cell death IL-1 secretion and gasdermin D (GSDMD)-mediated pore formation in liposomes within human and murine cellular models Mechanistically disulfiram elevates intracellular reactive oxygen species (ROS) concentrations in the presence of copper initiating copper-dependent cell death Additionally disulfiram disrupts the ubiquitin-proteasome protein degradation pathway in tumor cells impairing cellular waste clearance and inducing apoptosis Research demonstrates its potential anti-cancer activity particularly synergistically enhanced by copper supplementation and cardioprotective effects against ischemia-reperfusion-induced damage
Apexbio Technology LLC AZD7762(Synonyms: AZD-7762, AZD 7762, 860352-01-8), 10mM (in 1mL DMSO), CAS: 860352-01-8.
AZD7762 (CAS No 860352-01-8) is an ATP-competitive inhibitor targeting the checkpoint kinases Chk1 and Chk2 regulatory enzymes activated upon DNA damage that control cell-cycle progression through phosphorylation of CDC25 phosphatases By competitively binding the ATP-binding pocket of Chk1 AZD7762 blocks Chk1-mediated phosphorylation of CDC25C exhibiting an IC50 of approximately 5 nM and Ki of 3 6 nM This inhibition prevents DNA damage-induced cell cycle arrest and interrupts DNA repair mechanisms promoting apoptosis in tumor cells Consequently AZD7762 acts as a chemosensitizing agent enhancing the cytotoxic effects of DNA-damaging therapies in oncology research